This system might be with the induction of hepatic microsomal enzymes that metabolize the antibiotic. If phenobarbital and doxycycline are administered concurrently, the clinical reaction to doxycycline need to be monitored closely. Phenytoin, sodium valproate, valproic acid: The impact of barbiturates to the metabolism of phenytoin seems to get variable. https://clintm877fsd1.blog4youth.com/profile