Pentobarbital boosts toxicity of buprenorphine, long-acting injection by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of buprenorphine and benzodiazepines or other CNS depressants increases hazard of adverse reactions which includes overdose, respiratory melancholy, and Demise. Cessation of benzodiazepines or other CNS depressants is desired usually. pen... https://jeffreycxnch.imblogs.net/84181660/fascination-about-pentobarbital-lethal-dose